COA Available
Performance In Stock Research Use Only
IGF-1 DES
1mg · Lyophilized Powder · Purity ≥99%
IGF-DES (Des(1-3)IGF-1) is a naturally occurring truncated form of IGF-1 in which the first three N-terminal amino acids are absent, virtually eliminating affinity for IGF-binding proteins. This structural feature makes it a well-characterised research tool for studying direct, unattenuated IGF-1 receptor activation and local growth factor signalling dynamics in cell and tissue models.
$69.99 CAD
Purchase Options
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
The deletion of the N-terminal tripeptide in IGF-DES results in negligible IGFBP binding, distinguishing it from both native IGF-1 and the LR3 variant and enabling researchers to study receptor-driven intracellular cascades with minimal interference from endogenous binding proteins. IGF-DES has been applied in preclinical models examining cell proliferation, survival signalling, and local tissue growth factor responses. Each vial is manufactured to research-grade purity and supplied with a certificate of analysis. Supplied exclusively for laboratory and research use.
Preclinical cell signalling studies have employed IGF-DES to examine direct IGF-1 receptor occupancy and the downstream activation of PI3K/Akt and MAPK pathways in the absence of IGFBP competition. Its utility as a model compound lies in its ability to represent the bioavailable, receptor-accessible fraction of IGF-1 that would otherwise be sequestered by binding proteins in vivo. Research has also used IGF-DES in comparative studies alongside native IGF-1 and LR3 to characterise the functional contribution of the N-terminal domain. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | IGF-1 DES |
| Format | Lyophilized Powder |
| Size | 1mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-IGF1DE-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $69.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-IGF1DE-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Store lyophilised IGF-DES at −20°C, protected from light and moisture, in its original sealed vial. Avoid repeated freeze-thaw cycles, which can compromise peptide integrity and reduce assay reproducibility. After reconstitution, aliquot into single-use volumes and store at −80°C; consult the lot-specific COA for validated stability data.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
Research Solution Reference Calculator
Pre-filled with 1mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
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For research-use calculations only. Always verify measurements independently — not medical guidance.
Questions before you order?
Browse the FAQ for documentation, storage, and sourcing answers, or contact our support team directly. We aim to respond to all research procurement inquiries within one business day.
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