COA Available
Performance In Stock Research Use Only
MOTS-c
10mg · Lyophilized Powder · Purity ≥99%
MOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded within the 12S rRNA region of the mitochondrial genome — a member of the emerging class of mitochondria-derived peptides (MDPs). Under metabolic stress conditions, MOTS-c translocates from mitochondria to the nucleus via an AMPK-dependent mechanism, where it modulates nuclear gene expression related to glucose metabolism and cellular energy homeostasis.
$49.99 CAD
Purchase Options
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
MOTS-c represents a growing area of research interest in mitochondrial-nuclear communication, particularly in the context of metabolic stress, insulin sensitivity, and cellular ageing. Studies have observed that plasma MOTS-c levels decline with advancing age in both human cohorts and animal models, positioning it as a relevant research tool for investigations into age-associated metabolic function and AMPK pathway biology. BME Health supplies MOTS-c at research-grade purity with full COA documentation per batch. Supplied exclusively for laboratory and research use.
Preclinical investigations have used MOTS-c to probe AMPK pathway activation, glucose uptake dynamics, and adipogenesis regulation in cell-based and animal model systems. Research into its nuclear translocation mechanism has employed MOTS-c as a probe to study the broader biology of mitochondrial retrograde signalling and its role in transcriptional regulation. Comparative studies have noted its ability to modulate insulin signalling pathways in preclinical metabolic models independently of canonical hormonal inputs. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | MOTS-c |
| Format | Lyophilized Powder |
| Size | 10mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-MOTSC1-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $49.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-MOTSC1-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Store lyophilised MOTS-c at −20°C in its original sealed vial, protected from light and moisture. Avoid repeated freeze-thaw cycles, as the short peptide chain is susceptible to aggregation and degradation with thermal cycling. Reconstituted solutions should be aliquoted and stored at −80°C; consult the lot-specific COA for validated stability parameters.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
Research Solution Reference Calculator
Pre-filled with 10mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
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For research-use calculations only. Always verify measurements independently — not medical guidance.
Questions before you order?
Browse the FAQ for documentation, storage, and sourcing answers, or contact our support team directly. We aim to respond to all research procurement inquiries within one business day.
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